Memory status and self-assessment of asthenia in HIV-infected patients receiving antiretroviral therapy


DOI: https://dx.doi.org/10.18565/epidem.2022.12.3.65-70

Belyaeva V.V., Sokolova E.V., Kozyrina N.V., Kuimova V.A., Kulabukhova E.I., Goliusova M.D.

1) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 2) Peoples’ Friendship University of Russia, Moscow, Russia
Objective. To assess memory function and asthenia in HIV-infected patients receiving antiretroviral therapy (ART).
Subjects and methods. In September to December 2021, a survey and testing were done in 73 patients: 47 men and 26 women aged 18 to 62 years. Their median age was 39.0 years; 69.9% of the respondents had higher and incomplete higher education; 21.9% had secondary specialized education. All the patients received ART; the median CD4 lymphocyte count at the time of the survey was 636.5 cells/μL. All the respondents had an undetectable viral load. The patients were given a subjective asthenia rating scale (Multidimensional Fatigue Inventory (MFI-20)). Auditory verbal memory was assessed using the results of tests for memorizing 6 words in a given order and 2 series of 3 words. Visual memory was evaluated by the results of a test for memorization of 6 figures.
Results. The span of auditory verbal memory in direct reproduction was within the normal range in most of the subjects. At the same time, this indicator in delayed reproduction showed a more pronounced deficit than that in the direct reproduction. Under the complicated conditions for verbal presentation (the use of homogeneous interference), there was a substantial decrease in the ability to directly reproduce verbal stimulus information. None of the subjects was able to repeat 2 series of 3 words at 20 minutes after presentation. There was no evidence for a statistically significant effect of age, gender, a history of trauma, psychoactive substances use, and previous COVID-19 infection on auditory verbal memory function in the analyzed group of patients receiving ART. The most unfavorable level of asthenia self-assessment was noted on the lower motivation scale. Visual memory in the examined patients was better preserved than auditory verbal memory.
Conclusion. When consulting on adherence to follow-up and treatment of HIV infection, it is advisable to use visual methods for information transfer more widely, for example, along with verbal ones, to employ written recommendations.
Keywords: auditory verbal memory. visual memory, asthenia, HIV infection
Read entire article

Literature

1. Nightingale S., Dreyer A.J., Saylor D., Gisslén M., Winston A., Joska J. A. Moving on From HAND: Why We Need New Criteria for Cognitive Impairment in Persons Living With Human Immunodeficiency Virus and a Proposed Way Forward. Clin. Infect. Dis. 2021; 73(6): 1113–8. DOI: 10.1093/cid/ciab366.


2. Беляева В.В., Соколова Е.В., Козырина Н.В., Куимова У.А., Голиусова М.Д., Кулабухова Е.И. Изучение маркеров когнитивного дефицита у ВИЧ-инфицированных пациентов, принимающих АРТ. VI Санкт-Петербургский форум по ВИЧ-инфекции с международным участием. Журнал инфектологии 2021; 13(3), приложение 1: 7–13.


Belyaeva V.V., Sokolova E.V., Kozyrina N.V., Kuimova U.A., Goliusova M.D., Kulabukhova E.I. [Study of markers of cognitive deficits in HIV-infected patients taking ART. VI St. Petersburg Forum on HIV infection with international participation]. J. Infectology. 2021; 13(3), suppl. 1: 7–13. (In Russ.).


3. Shahid A., Wilkinson K., Marcu S., Shapiro C.M. Multidimensional Fatigue Inventory (MFI). In: STOP, THAT and One Hundred Other Sleep Scales. Vol. 21. New York, NY: Springer New York, 2011: 241–3. DOI: 10.1007/978-1-4419-9893-4_57


4. Захаров В.В. Нейропсихологические тесты. Необ­ходимость и возможность применения. Consilium Medicum 2011; 13(2): 98–106.


Zakharov V.V. [Neuropsychological tests. Necessity and applicability]. Consilium Medicum 2011; 13(2): 98–106. (In Russ.).


5. Беляева В.В., Соколова Е.В., Козырина Н.В., Куимова У.А., Голиусова М.Д., Кулабухова Е.А. Cостояние зрительной памяти у пациентов, инфицированных ВИЧ, на фоне приема антиретровирусной терапии. Инфекционные болезни в современном мире: эволюция, текущие и будущие угрозы: сборник трудов ХIV Ежегодного Всероссийского Конгресса по инфекционным болезням имени академика В.И. Покровского, Москва, 28–30 марта 2022 г. М.: ММА, 2022. 22 c.


Belyaeva V.V., Sokolova E.V., Kozyrina N.V., Kuimova U.A., Goliusova M.D., Kulabukhova E.A. [State of visual memory in HIV-infected patients against the background of antiretroviral therapy. Infectious diseases in the modern world: evolution, current and future threats: Proceedings of the XIV Annual All–Russian Congress on Infectious Diseases named after Academician V.I. Pokrovsky, Moscow, March 28–30, 2022]. Moscow: Medical Marketing Agency, 2022. 22 p. (In Russ.).


About the Autors

Valentina V. Belyaeva МD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; labora-et-ora@yandex.ru;: http://orcid.org/0000-0002-4621-7892
Ekaterina V. Sokolova, Cand. Med. Sci., Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; ekaterinasokolova007@rambler.ru; http://orcid.org/0000-0002-2001-8772
Nadezhda V. Kozyrina, Cand. Med. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; nad-kozyrina@yandex.ru; htpp://orcid.org/0000-0001-5134-0054
Ulyana A. Kuimova, Cand. Med. Sci., Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; ulyanakuimova@gmail.com;: http://orcid.org/0000-0002-1101-151X
Ekaterina I. Kulabukhova, Cand. Med. Sci., Infectiologist, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Head, Laboratory of the Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, RUDN University, Moscow, Russia, ekulabukhova@mail.ru; https://orcid.org/0000-0003-3645-7275
Marina D. Goliusova, Infectiologist, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; mad2501@yandex.ru; https://orcid.org/ 0000-0002-5325-6857


Similar Articles

Back to Content

Бионика Медиа