Memory status and self-assessment of asthenia in HIV-infected patients receiving antiretroviral therapy


DOI: https://dx.doi.org/10.18565/epidem.2022.12.3.65-70

Belyaeva V.V., Sokolova E.V., Kozyrina N.V., Kuimova V.A., Kulabukhova E.I., Goliusova M.D.

1) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 2) Peoples’ Friendship University of Russia, Moscow, Russia
Objective. To assess memory function and asthenia in HIV-infected patients receiving antiretroviral therapy (ART).
Subjects and methods. In September to December 2021, a survey and testing were done in 73 patients: 47 men and 26 women aged 18 to 62 years. Their median age was 39.0 years; 69.9% of the respondents had higher and incomplete higher education; 21.9% had secondary specialized education. All the patients received ART; the median CD4 lymphocyte count at the time of the survey was 636.5 cells/μL. All the respondents had an undetectable viral load. The patients were given a subjective asthenia rating scale (Multidimensional Fatigue Inventory (MFI-20)). Auditory verbal memory was assessed using the results of tests for memorizing 6 words in a given order and 2 series of 3 words. Visual memory was evaluated by the results of a test for memorization of 6 figures.
Results. The span of auditory verbal memory in direct reproduction was within the normal range in most of the subjects. At the same time, this indicator in delayed reproduction showed a more pronounced deficit than that in the direct reproduction. Under the complicated conditions for verbal presentation (the use of homogeneous interference), there was a substantial decrease in the ability to directly reproduce verbal stimulus information. None of the subjects was able to repeat 2 series of 3 words at 20 minutes after presentation. There was no evidence for a statistically significant effect of age, gender, a history of trauma, psychoactive substances use, and previous COVID-19 infection on auditory verbal memory function in the analyzed group of patients receiving ART. The most unfavorable level of asthenia self-assessment was noted on the lower motivation scale. Visual memory in the examined patients was better preserved than auditory verbal memory.
Conclusion. When consulting on adherence to follow-up and treatment of HIV infection, it is advisable to use visual methods for information transfer more widely, for example, along with verbal ones, to employ written recommendations.

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About the Autors


Valentina V. Belyaeva МD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; labora-et-ora@yandex.ru;: http://orcid.org/0000-0002-4621-7892
Ekaterina V. Sokolova, Cand. Med. Sci., Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; ekaterinasokolova007@rambler.ru; http://orcid.org/0000-0002-2001-8772
Nadezhda V. Kozyrina, Cand. Med. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; nad-kozyrina@yandex.ru; htpp://orcid.org/0000-0001-5134-0054
Ulyana A. Kuimova, Cand. Med. Sci., Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; ulyanakuimova@gmail.com;: http://orcid.org/0000-0002-1101-151X
Ekaterina I. Kulabukhova, Cand. Med. Sci., Infectiologist, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Head, Laboratory of the Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, RUDN University, Moscow, Russia, ekulabukhova@mail.ru; https://orcid.org/0000-0003-3645-7275
Marina D. Goliusova, Infectiologist, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; mad2501@yandex.ru; https://orcid.org/ 0000-0002-5325-6857


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