Русский
Connectivity of HIV-infection epidemics in the Republic of Armenia and the Russian Federation
DOI: https://dx.doi.org/10.18565/epidem.2023.13.3.27-34
Kireev D.E., Kirichenko A.A., Osadchaya O.A., Saleeva D.V., Lapovok I.A., Lopatukhin A.E., Shlykova A.V., Ladnaia N.N., Grigoryan T R., Petrosyan A.R., Sargatyan T.A., Ovakimyan E.M., Martoyan S.V., Kazaryan O.K., Ovsepyan T.V., Sarkisyants N.K., Pokrovsky V.V., Akimkin V.G.
1) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 2) National Center for Infectious Diseases, Ministry of Health of the Republic of Armenia, Yerevan, Republic of Armenia
Materials and methods. 1009 HIV nucleotide sequences of the pol region and accompanying depersonalized information about patients obtained under the orders of the Government of the Russian Federation carried out in 2016–2021 were studied. To assess the connectivity of the HIV epidemic, sequences from the Los Alamos database and the collection of Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being were also analyzed. The BLAST tool, phylogenetic and cluster analysis were applied to the resulting pool of sequences.
Results. Among the analyzed HIV sequences of Armenian citizens, 87.2% belonged to subsubtype A6, 5.6% - to subtype B, 2.7% – to CRF63_02A6, and 1.9% – to CRF02_AG. Other genetic variants were less common (1%). The largest number of genetically related HIV sequences were of Russian origin (44.52%), followed by the origin from Republic of Belarus (10.59%) and the USA (8.04%). Using cluster analysis, it was found that significantly more often mixed AM-RU clusters consisted of male patients with homosexual transmission, living in the suburbs of Yerevan, whose infection presumably occurred in Russia.
Conclusion. Bioinformatic analysis of HIV nucleotide sequences obtained from citizens of the Republic of Armenia, in combination with HIV genetic variants available today, has shown a high genetic similarity between the HIV sequences in Armenia and the Russian Federation.
Literature
1. Покровский В.В., Улумбекова Г.Э., Петрачков И.В. Организация медицинской помощи при инфекции, вызываемой вирусом иммунодефицита человека. ОРГЗДРАВ: новости, мнения, обучение. Вестник ВШОУЗ 2022; 8(2): 108–30. DOI: https://doi.org/10.33029/2411-8621-2022-8-2-108-130. Pokrovsky V.V., Ulumbekova G.E., Petrachkov I.V. (Organization of medical care in case of infection caused by the human immunodeficiency virus). ORGZDRAV: news, opinions, training. Vestnik VSHOUZ. 2022; 8(2): 108–30. (In Russ.). DOI: https://doi.org/10.33029/2411-8621-2022-8-2-108-130. 2. Ладная Н.Н., Покровский В.В., Соколова Е.В., Чекрыжова Д.Г., Киржанова В.В. Распространение инфекции, вызываемой вирусом иммунного дефицита человека, на территориях Российской Федерации в 2021 г. Эпидемиол. инфекц. болезни. Актуал. вопр. 2022; 12(3): 12–8. DOI: https://dx.doi.org/10.18565/epidem.2022.12.3.12-8 Ladnaia N.N., Pokrovsky V.V., Sokolova E.V., Chekryzhova D.G., Kirzhanova V.V. (Prevalence of human immune deficiency virus infection in the territories of the Russian Federation in 2021). Epidemiоlоgy and infectious diseases. Сurrent items 2022; 12(3): 12–8. (In Russ.). DOI: https: //dx.doi.org/10.18565/epidem.2022.12.3.12-8 3. HIV Epidemiological surveillance in the Republic of Armenia 2018 Annual Report. https://ecom.ngo/wp-content/uploads/2018/12/IBBS_ARMENIA_ 2018_eng_FINAL.pdf 4. International Organization for Migration. (2013). Report on Household Survey on Migration in Armenia. http://publications.iom.int/ bookstore/index. php?main_p.oduct_info&cPath=41_7&products_id=1400 5. Ministry of Health, National Center for AIDS Prevention. (2017) Biological and Behavioral Surveillance Survey on Armenian, Male, Seasonal Labor Migrants in Rural Communities in Armenia, 2016. http://www.armaids. am/images/pdf/Rural_migrant_survey_report_arm_eng.pdf 6. Nduva G.M., Otieno F., Kimani J., McKinnon L.R., Cholette F., Sandstrom P. et al. Phylogeographic Assessment Reveals Geographic Sources of HIV-1 Dissemination Among Men Who Have Sex With Men in Kenya. Frontiers in Microbiology, 2022; (13): 843330. https://doi.org/10.3389/fmicb.2022. 843330 7. Pimentel V., Pingarilho M., Alves D., Diogo I., Fernandes S., Miranda M. et al. Molecular Epidemiology of HIV-1 Infected Migrants Followed up in Portugal: Trends between 2001–2017. Viruses 2020; 12(3), 268. https://doi.org/10.3390/v12030268 8. Ratmann O., Kagaayi J., Hall M., Golubchick T., Kigozi G., Xi X. et al. Rakai Health Sciences Progra пm and the Pangea HIV Consortium. Quantifying HIV transmission flow between high-prevalence hotspots and surrounding communities: a population-based study in Rakai, Uganda. The Lancet HIV The Lancet HIV 2020; 7(3): e173–e183. https://doi.org/ 10.1016/S2352-3018(19)30378-9. 9. Kirichenko A., Kireev D., Lopatukhin A., Murzakova A., Lapovok I., Saleeva D. et al. Prevalence of HIV-1 drug resistance in Eastern European and Central Asian countries. PLoS ONE 2022; 17(1): e0257731. https://doi.org/ 10.1371/journal.pone.0257731 10. Kirichenko A., Kireev D., Lapovok I., Shlykova A., Lopatukhin A., Pokrovskaya A. et al. Prevalence of Pretreatment HIV-1 Drug Resistance in Armenia in 2017–2018 and 2020–2021 following a WHO Survey. Viruses 2022; 14(11): 2320. https://doi.org/10.3390/v14112320 11. HIV/AIDS surveillance in Europe: 2022– 2021 data. WHO Regional Office for Europe, European Centre for Disease Prevention and Control. Copenhagen: WHO Regional Office for Europe, 2022. 12. Migration Survey on the Relationship between Skills, Migration and Development in Armenia. European Training Foundation, 2011. http://www. crrc.am/hosting/file/_static_content/projects/Migration_and_skills_2011/Migration_and_skills_Armenia.pdf 13. Migration and Development. Armenian Country Study. International Labour Organization. Yerevan, 2010. http://www.smsmta.am/upload/Migration%20and%20Development_Study_in_English.pdf 14. Осадчая О.А., Ерошкин П.В., Кириченко А.А., Лаповок И.А., Салеева Д.В., Лопатухин А.Э. и др. Изучение передачи лекарственной устойчивости ВИЧ-1 в Республике Армения с помощью биоинформатических методов. Эпидемиол. инфекц. болезни. Актуал. вопр. 2021; 11(4): 53–60. DOI: 10.18565/epidem.2021.11.4.53–60. Osadchaya O.A., Eroshkin P.V., Kirichenko A.A., Lapovok I.A., Saleeva D.V., Lopatukhin A.E. et al. (Studying the transmission of HIV-1 drug resistance in the Republic of Armenia using bioinformatics methods). Epidemiоlоgy and infectious diseases. Сurrent items 2021; 11(4): 53–60. (In Russ.). DOI: 10.18565/epidem.2021.11.4.53–60 15. Лаповок И.А., Лопатухин А.Э., Киреев Д.Е., Казеннова Е.В., Лебедев А.В., Бобкова М.Р. и др. Молекулярно-эпидемиологический анализ вариантов ВИЧ-1, циркулировавших в России в 1987–2015 гг. Терапевтический архив 2017; 89(11): 44–9. DOI: 10.17116/terarkh2017891144-49 Lapovok I.A., Lopatukhin A.E., Kireev D.E., Kazennova E.V., Lebedev A.V., Bobkova M.R. et al. (Molecular epidemiological analysis of HIV-1 variants circulating in Russia in 1987–2015). Therapeutic archive 2017; 89(11): 44–9. DOI: 10.17116/terarkh2017891144-49 16. Еремин В.Ф., Гасич Е.Л., Сосинович С.В., Суетнов О.Н., Грушко П.Н., Грушко Т.П. и др. Молекулярная эпидемиология ВИЧ/СПИД в Беларуси (2008–2011). Здравоохранение (Минск) 2012; (1): 25–34. Eremin V.F., Gasich E.L., Sosinovich S.V., Suetnov O.N., Grushko P.N., Grushko T.P. et al. (Molecular epidemiology of HIV/AIDS in Belarus (2008–2011)). Healthcare (Minsk). 2012; (1): 25–34. (In Russ.).
About the Autors
Dmitry E. Kireev, Cand. Biol. Sci., Head, Laboratory for Diagnostics and Molecular Epidemiology of HIV Infection, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; dmitkireev@yandex.ru; https://orcid.org/0000-0002-7896-2379
Alina A. Kirichenko, Researcher, Laboratory for Diagnostics and Molecular Epidemiology of HIV Infection, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; kotova-kirichenko@mail.ru; http://orcid.org/0000-0002-7116-0138
Olga A. Osadchaya, Junior Researcher, Laboratory of Diagnostics and Molecular Epidemiology of HIV Infection, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; osadchaya96@yandex.ru; https://orcid.org/0000-0003-1543-5579
Daria V. Saleeva, Researcher, Laboratory of Diagnostics and Molecular Epidemiology of HIV-infection, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; dasha_saleeva@inbox.ru; https://orcid.org/0000-0002-5870-5594
Ilya A. Lapovok, Cand. Biol. Sci., Senior Researcher, Laboratory of Diagnostics and Molecular Epidemiology of HIV-infection, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; i_lapovok@mail.ru; https://orcid.org/0000-0002-6328-1415
Alexey E. Lopatukhin, Researcher, Laboratory of Diagnostics and Molecular Epidemiology of HIV-infection, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; a.lopatukhin@gmail.com; https://orcid.org/0000-0002-2826-699X
Anastasia V. Shlykova, Researcher, Laboratory of Diagnostics and Molecular Epidemiology of HIV-infection, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; murzakova_a.v@mail.ru; https://orcid.org/0000-0002-1390-8021
Natalia N. Ladnaia, Cand. Biol. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; nladnaia@hotmail.com; https://orcid.org/0000-0003-2994-151X
Trdat R. Grigoryan, Monitoring and Evaluation Specialist, National Center for Infectious Diseases, Ministry of Health of the Republic of Armenia, Yerevan, Republic of Armenia; gtrdat@yahoo.com; http://orcid.org/0000-0002-7319-7444
Arshak R. Petrosyan, Laboratory Physician, Laboratory of PCR, Microbiology, Virology and Genetics, National Center for Infectious Diseases, Ministry of Health of the Republic of Armenia, Yerevan, Republic of Armenia; a_petrosyan@list.ru
Tatevik A. Sargatyan, Laboratory Doctor, Laboratories of PCR, Microbiology, Virology, and Genetics, National Center for Infectious Diseases,Ministry of Health of the Republic of Armenia, Yerevan, Republic of Armenia; sarhatyantatev@mail.ru
Ermis M. Hovakimyan, Head, Сlinical Department, National Center for Infectious Diseases, Ministry of Health of the Republic of Armenia, Yerevan, Republic of Armenia; hovakimyan80@mail.ru
Siranush V. Martoyan, Epidemiologist, National Center for Infectious Diseasesм, Ministry of Health of the Republic of Armenia, Yerevan, Republic of Armenia, smartoyan@gmail.com; https://orcid.org/0000-0002-2067-9503
Ovsep K. Kazaryan, Cand. Biol. Sci., Researcher, National Center for Infectious Diseases, Ministry of Health of the Republic of Armenia, Yerevan, Republic of Armenia,: thovsep@gmail.com; https://orcid.org/0000-0001-5612-8933
Tamara V. Hovsepyan, Head of Laboratory, National Center for Infectious Diseases, Ministry of Health of the Republic of Armenia, Yerevan, Republic of Armenia; thovsep@gmail.com
Narina K. Sarkisyants, Cand. Med. Sci., Deputy Director, National Center for Infectious Diseases, Ministry of Health of the Republic of Armenia, Yerevan, Republic of Armenia; sknarina70@mail.ru
Professor Vadim V. Pokrovsky, Academician of the Russian Academy of Sciences, MD, Head, Specialized Research Department of Epidemiology and Prevention of AIDS, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; pokrovsky.vad@yandex.ru; https://orcid.org/0000-0002-9514-7288; Scopus Author ID: 7202457043
Professor Vasily G. Akimkin, Academician of the Russian Academy of Sciences, MD, Director, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; vgakimkin@yandex.ru; https://orcid.org/0000-0003-4228-9044
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