Analysis of the effectiveness of specific prevention of hepatitis B in a risk group


DOI: https://dx.doi.org/10.18565/epidem.2019.9.3.39-46

Eremeeva Zh.G., Fazylov V.Kh., Manapova E.R., Yakupova F.M.

1) Kazan State Medical University, Ministry of Health of Russia, Kazan, Russia; 2) Republican Clinical Dermatovenerology Dispensary, Kazan, Russia
Objective. To analyze of the effectiveness of specific prevention of hepatitis B (HB), by assessing postvaccination immunity in health care workers.
Material and methods. Trends in the incidence of acute HB were studied in the Russian Federation and in the Republic of Tatarstan in 2008–2017. An epidemiological analysis of 167 outpatient records of healthcare workers was carried out to estimate the rates of HB vaccination and its coverage. Anti-HBs antibody levels were determined using ELISA. The relationship of the level of anti-HBs antibodies to the age of the examinees and the long standing of vaccination was studied. The findings were statistically processed using the generally accepted methods for medical statistics.
Results. In 2008–2017, the incidence of acute HB showed a significant tendency to decrease in both Russia and the Republic of Tatarstan. In the examined group of health care workers, the rate of vaccination coverage was 97% and that of vaccination was 95%. Studying the intensity of post-vaccination immunity revealed that the immune layer was 41%.
Conclusion. The low level of anti-HBs in 59% of cases (it was absent in 12%) suggests that there is a risk for HB virus infection and a need for selective revaccination in health care workers.
Keywords: hepatitis B, immunity, vaccination
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About the Autors

Zhanna G. Еremeeva, Epidemiologist, Republican Clinical Dermatovenerology Dispensary;  Assistant Lecturer, Department of Epidemiology and Evidence-Based Medicine, Kazan State Medical University, Ministry of Health of Russia; e-mail: Z.Eremeeva@tatar.ru; ORCID: https://orcid.org/0000-0003-2711-0624
Vildan Kh. Fazylov, MD, Professor, Department of Infectious Diseases, Kazan State Medical University, Ministry of Health of Russia; e-mail: fazylov47@inbox.ru; ORCID: http://orcid.org/0000-0003-4333-6316
Elvira R. Manapova, MD, Associate Professor, Department of Infectious Diseases, Kazan State Medical University, Ministry of Health of Russia; e-mail:  elveram@yandex.ru; ORCID: http://orcid.org/0000-0003-4300-4602
Farida M. Yakupova, Cand. Med. Sci., Assistant Lecturer, Department of Epidemiology and Evidence-Based Medicine, Kazan State Medical University, Ministry of Health of Russia; e-mail: faridaleto@mail.ru; ORCID: http://orcid.org/ 0000-0001-8416-0885


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