New possibilities of predicting the outcomes of antiviral therapy in patients with chronic hepatitis B


DOI: https://dx.doi.org/10.18565/epidem.2018.3.47-50

Zaitseva E.A., Popova L.L., Konstantinov D.Yu., Nedugov G.V.

1 Samara State Medical University, Ministry of Health of Russia, Samara, Russia; 2 Samara Regional Forensic Medical Examination Bureau, Samara, Russia

Objective. To develop a procedure for predicting the outcomes of antiviral therapy with entecavir in HBeAg-negative patients with chronic hepatitis B (CHB).
Subjects and methods. A total of 154 primary patients with HBeAg-negative CHB were examined. The diagnosis was made on the basis of clinical, epidemiological, biochemical, instrumental, serological, and molecular genetic studies. The findings were subjected to mathematical and statistical processing that included descriptive assessment, discriminant analysis, and distribution normality analysis using the χ2 test and the Kolmogorov–Smirnov goodness-of-fit test.
Conclusion. A discriminant model has been developed, which can predict the outcome of antiviral therapy with entecavir in patients with HBeAg-negative CHB before treatment, with the probability of an erroneous prognosis of less than 10-26, which is recommended to be used in clinical practice to treat this category of patients.

Keywords: serum and induced α-interferon, entecavir, chronic viral hepatitis B, antiviral therapy, prognosis
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Literature

  1. Konstantinova E.A. [Clinical and laboratory characteristics of the course of recurrence of НВеАg-negative variant of chronic hepatitis B In patients with high and low levels of HBsAg]. Aspirantskу vestnik Povolzhуa 2010; (7–8): 52–5. (In Russ.).
  2. Lok A.S.F., McMahon B.J. Chronic hepatitis B. Hepatology 2007; (45): 507–39.
  3. Tkachenko L.I., Maleev V.V., Sannikova I.V., Pase­chnikov V.D., Titorenko M.V. [Comparative analysis of the effectiveness of nucleoside analogues in the treatment of patients with chronic hepatitis B]. Infekcionnye bolezni 2012; (2): 2–7. (In Russ.).

For citations: Zaitseva E.A., Popova L.L., Konstantinov D.Yu., Nedugov G.V. New possibilities of predicting the outcomes of antiviral therapy in patients with chronic hepatitis B. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2018; (3):47–50


About the Autors

For correspondence:
Dmitry Yu. Konstantinov, Сand. Med. Sci., Associate Professor, Department of Infectious Diseases with Course of Epidemiology, Samara State Medical University, Ministry of Health of Russia
Address: 89, Chapaevskaya St., Samara 443099, Russia
Telephone/fax: +7(846) 260-06-39
E-mail: dk.samgmu@mai
ORCID: http://orcid.org/0000-0002-6177-8487
Information about the authors:
Ekaterina A. Zaitseva, Assistant Lecturer, Department of Infectious Diseases with Course of Epidemiology, Samara State Medical University, Ministry of Health of Russia, Samara, Russia; e-mail: inf-samgmu @yandex.ru; ORCID: http://orcid.org/0000-0002-4590-3591
Larisa L. Popova, МD, Professor, Department of Infectious Diseases with Course of Epidemiology, Samara State Medical University, Ministry of Health of Russia, Samara, Russia; е-mail: ll.popova@mail.ru; ORCID: http://orcid.org/0000-0003-0549-361X
German V. Nedugov, Сand. Med. Sci., Head, Histology Department, Samara Regional Forensic Medical Examination Bureau, Samara, Russia; e-mail: nedugovh@mail.ru; ORCID: http://orcid.org/0000-0002-7380-3766


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