The relationship between infections and allergic diseases


Usenko D.V., Gorelova E.A.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
In recent years, the relationship between infectious and allergic diseases has attracted the great attention of scientists. This literature review analyzes investigations of the role of a number of infectious agents as a trigger of allergic diseases (particularly, asthma and atopic dermatitis). Noteworthy are the data suggesting that some pathogens of bacterial and viral infections play a protective role in the manifestation of atopy. Despite many years of investigations, the clinical and pathogenetic aspects of the impact of allergic diseases on the course of bacterial and viral infections remain unstudied, which requires further investigations and elaboration of appropriate rehabilitation programs.

Literature


  1. Wills-Karp M., Santeliz J., Karp C.L. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat. Rev. Immunol. 2001; 1(1): 69–75.
  2. Strachan D.P. Hay fever, hygiene, and household size. BMJ. 1989; 299 (6710): 1259–60.
  3. Schaub B., Lauener R., von Mutius E. The many faces of the hygiene hypothesis. J. Allergy Clin. Immunol. 2006; 117(5): 969–77.
  4. Martinez F.D., Holt P.G. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999; 354(Suppl 2): SII12–5.
  5. Bach J.F. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 2002; 347: 911–20.
  6. Yazdanbakhsh M., van den Biggelaar A., Maizels R.M. Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. Trends Immunol. 2001; 22: 372–7.
  7. Eisenbarth S.C., Piggott D.A., Huleatt J.W. et al. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 2002; 196: 1645–51.
  8. Braun-Fahrlander C., Riedler J., Herz U. et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N. Engl. J. Med. 2002; 347: 869–77.
  9. Belkaid Y., Piccirillo C.A., Mendez S. et al. CD41CD251 regulatory T cells control Leishmania major persistence and immunity. Nature 2002; 420: 502–7.
  10. Herz U., Lacy P., Renz H., Erb K. The influence of infections on the development and severity of allergic disorders. Current Opinion in Immunology 2000; 12: 632–40.
  11. Long C.E., McBride J.T., Hall C.B. Sequelae of respiratory syncytial virus infections. A role for intervention studies. Am. J. Respir. Crit. Care Med. 1995; 151: 1678–81.
  12. Bianco A.,Whiteman S.C., Sethi S.K. et al. Expression of intercellular adhesion molecule-1 (ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection? Clin. Exp. Immunol. 2000; 121: 339–45.
  13. Haitov M.R. [The role of respiratory viruses in the pathogenesis of bronchial asthma]. Immunologiya 2003; (1): 58–65. (In Russ.).
  14. Román M., Calboun W.J., Hinton K.L. et al. Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. Am. J. Respir. Cri.t Care Med. 1997; 156: 190–5.
  15. Bendelja K., Gagro A., Bace A. et al. Predominant type-2 response in infants with respiratory syncytial virus (RSV) infection demonstrated by cytokine flow cytometry. Clin. Exp. Immunol. 2000; 121: 332–8.
  16. Jacoby D.B., Fryer A.D. Interaction of viral infections with muscarinic receptors. Clin. Exp. Allergy 2001; 29(Suppl 2): 59–64.
  17. Flynn M.G.L. Respiratory symptoms, bronchial responsiveness, and atopy in Fijan and Indian children. Am. J. Respir. Crit. Care Med. 1994; 150: 415–20.
  18. Kneyber M.C.J., Steyerberg E.W., de Groot R., Moll H.A. Long-term effects of respiratory syncytial virus (RSV) bronchiolitis in infants and young children: a quantitative review. Acta Paediatr. 2000; 89(6): 654–60.
  19. Stein R.T., Sherrill D., Morgan W.J. et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999; 354: 541–5.
  20. Anderson H.R. The epidemiological and allergic features of asthma in the New Guinea Highlands. Clin. Allergy . 1974; (4): 171–83.
  21. ISAAC Steering Committee. Worldwide variations in the prevalence of atopic diseases: the International Study of Asthma and Allergies in Childhood (ISAAC). Lancet 1998; 351: 1225–32.
  22. García-García M.L., Calvo C., Casas I. et al. Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5. Pediatr. Pulmonol. 2007; 42: 458–64.
  23. Khaitov M.R., Trofimov D.Yu., Petrova T.V., Yakovleva K.P., Yarcev M.N., Alekseev L.P., Ilina N.I. [Rhinovirus infection in atopic bronchial asthma in children]. Rossiyskiy allergologicheskiy zhurnal 2004; (1): 30–6. (In Russ.).
  24. Bianco A., Whiteman S.C., Sethi S.K. et al. Expression of intercellular adhesion molecule-1 (ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection? Clin. Exp. Immunol. 2000; 121: 339–45.
  25. Imani F., Proud D., Griffin D.E. Measles virus infection synergizes with IL-4 in IgE class switching. J. Immunol. 1999; 162(3): 1597–602.
  26. Marin J., Jeler-Kacar D., Levstek V., Macek V. Persistence of viruses in upper respiratory tract of children with asthma. J. Infect. 2000; 41(1): 69–72.
  27. Callow K.A. Influence of atopy on the clinical manifestations of coronavirus infection in adult volunteers. Clin. Exp. Allergy 2006; 18(2): 119–29.
  28. Kocabaş E., Yapicioğlu H., Yildizdaş D. et al. The prevalence of atopy in children with antibodies against hepatitis A virus and hepatitis B virus. Turk. J. Pediatr. 2006; 48(3): 189–96.
  29. Matricardi P.M., Rosmini F., Ferrigno L. et al. Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. BMJ 1997; 314: 999–1003.
  30. Jarvis D., Luczynska C., Chinn S., Burney P. The association of hepatitis A and Helicobacter pylori with sensitization to common allergens, asthma and hay fever in a population of young British adults. Allergy 2004; 59: 1063–7.
  31. Illi S., von Mutius E., Lau S. et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 2001; 322: 390–5.
  32. Firer M.A., Hosking C.S., Hill D.J. Possible role for rotavirus in the development of cows’ milk enteropathy in infants. Clin. Exp. Allergy 2006; 18(1): 53–61.
  33. Usenko D.V., Gorelov A.V., Shabalina S.V., Gorelova E.A. [Clinical and laboratory features of acute intestinal infections in children with atopic dermatitis]. Pediatriya. Zhurnal im. G.N. Speranskogo 2013; 92(1): 40–5. (In Russ.).
  34. Gorelova E.A., Olisova O.Yu., Usenko D.V. [Clinical and laboratory features of acute intestinal infections in children with atopic dermatitis]. Infekcionnye bolezni 2016; 14(1): 80–5. (In Russ.).
  35. Usenko D.V. [Acute intestinal infections in children with atopic dermatitis]. Dr. Med. Diss. Мoscow, 2013. https://search.rsl.ru/ru/record/01005059186 (In Russ.).
  36. Gorelova E.A. [Rotavirus infection in children with atopic dermatitis: course, outcomes, specifics of management in acute and recovery periods]. Cand. Med. Diss. Мoscow, 2016. http://www.crie.ru/pdf/disser1 (gorelova).pdf (In Russ.).
  37. Bach J.F. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 2002; 347: 911–20.
  38. Moore K.W., de Waal Malefyt R., Coffman R.L., O’Garra A. Interleukin-10 and the interleukin-10 receptor. Ann. Rev. Immunol. 2001; 19: 683–765.
  39. Liacopoulos P., Ben-Efraim S.. Antigenic competition. Prog. Allergy 1975; 18: 97–204.
  40. Schubert M.S. A superantigen hypothesis for the pathogenesis of chronic hypertrophic rhinosinusitis, allergic fungal sinusitis, and related disorders. Ann. Allergy Asthma Immunol. 2001; 87: 181–8.
  41. Akira S., Takeda K., Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001; 2: 675–80.
  42. Cremonini F., Gasbarrini A. Atopy, Helicobacter pylori and the hygiene hypothesis. Gastroenterology and Hepatology 2003; 15(6): 27–8.
  43. Klimkovich N.M., Vasileva M.M., Andrienko Ya.S., Klimkovich S.I. [The influence of Helicobacter pylori infection on the incidence of children with asthma, and levels of IL-10, IL-4 and IFN-γ in the serum]. Allergologiya i immunologiya v pediatrii 2008; 13: 6–9. (In Russ.).
  44. Hessel E., Van Oosterhout A., Van ark I. et al. Development of aiway hyperresponsiveness is dependent on IFN-gamma and independent of eosinophil infiltration. Am. J. Respir. Cell Mol. Biol. 1997; 16: 325–35.
  45. Belmer S.V., Gasilina T.V., Lukyanova E.M. [Agastroenterology manifestations of Helicobacter pylori infection]. Lechaschiy vrach 2002; (7–8): 72–5. (In Russ.).
  46. Galadari I.H., Sheriff M.O. The role of Helicobacter pylori in urticaria and atopic dermatitis. Skinmed. 2006; 5(4): 172–6.
  47. Corrado G., Luzzi I., Lucarelli S. et al. Positive association between Helicobacter pylori infection and food allergy in children. Scand. J. Gastroenterol. 1998; 33: 1135–9.
  48. Pelosi U., Porcedda G., Tiddia F. The inverse association of salmonellosis in infancy with allergic rhinoconjunctivitis and asthma at school-age: a longitudinal study. Allergy 2005; 60(5): 626–30.


About the Autors


For correspondence:
Denis V. Usenko, MD, Leading Researcher, Clinical Department of Infectious Diseases, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Address: 3a, Novogireevskaya St., Moscow 111123, Russia
Теlеphone: +7(495) 672-11-58
E-mail: dusenko@rambler.ru
Information about the authors:
Elena A. Gorelova, Cand. Med. Sci., Researcher, Clinical Department of Infectious Diseases, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: crie@pcr.ru


Similar Articles


Бионика Медиа