A virologic response as a hallmark of excellence: TDF/FTC or TDF/3TC

Kozyrina N.V., Yurin O.G.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow
In accordance with most guidelines, tenofovir disoproxil fumarate (TDF) that is usually combined with emtricitabine (FTC) is a constituent of the nucleoside basis for an antiretroviral therapy regimen. This combination is used as part of first-line antiretroviral therapy. TDF may be concurrently administered with lamivudine (3TC). The review describes the data of comparable retrospective studies of the virologic efficiency of TDF/FTC and TDF/3TC regimens. The given works show a better virologic response when using the TDF/FTC regimen. And along with this, there are investigations that have shown no difference in a virologic response when using these nucleoside bases in the therapy regimens. It is concluded that the virologic efficacy of the TDF/FTC combination cannot be at least extrapolated to other TDF combinations in clinical practice.


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About the Autors

For correspondence:
Kozyrina Nadezhda Vladimirovna, Cand. Med. Sci.; Researcher, Research Department of AIDS Epidemiology and Prevention, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Address: 15, Eighth Sokolinaya Gora St., Build. 2, Moscow 105275
Telephone: +7(495) 366-05-18
E-mail: nad-kozyrina@yandex.ru

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