Русский
Atypical course of dengue fever with a symptom complex of acute hepatitis
DOI: https://dx.doi.org/10.18565/epidem.2025.15.4.94-98
Pshenichnaya N.Yu., Khoreva V.V., Shipilov M.V., Luzhetskaya A.A.
1) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 2) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 3) M. F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia; 4) Smolensk State Medical University, Smolensk, Russia
This article presents a clinical case of an atypical dengue fever course characterized by the development of acute hepatitis in the absence of other typical clinical and laboratory manifestations of the disease, including skin rashes, leukopenia, thrombocytopenia, and coagulopathy. This phenomenon significantly complicated the diagnostic process and required a comprehensive approach to verifying the diagnosis, including differential diagnosis with a range of infectious and non-infectious diseases associated with liver damage. The relevance of this problem is attributable to the growing threat to public health associated with the expansion of dengue fever and the involvement of areas previously considered non-endemic in the epidemic. Of additional concern is the high risk of developing severe forms of the disease, including hemorrhagic ones, upon reinfection with a different serotype. The atypical clinical course of dengue fever emphasizes the need for a differential diagnosis with a thorough assessment of the epidemiological history, clinical manifestations, and laboratory parameters.
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About the Autors
Professor Natalia Yu. Pshenichnaya, MD, Head, Department of Infectious Diseases, Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russia; Deputy Director for Clinical and Analytical Work, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Professor, Department of Infectious Diseases, M.F. Vladimirsky Moscow Regional Scientific Research Clinical Institute Moscow, Russia; natalia-pshenichnaya@yandex.ru. https://orcid.org/0000-0003-2570-711X
Victoria V. Khoreva, Resident, Department of Infectious Diseases, Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russia, Moscow, Russia; vika2092000@mail.ru; https://orcid.org/0009-0008-7642-9264
Mikhail V. Shipilov, MD,, Professor, Department of Infectious Diseases, Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russia; Associate Professor, Department of Infectious Diseases with Epidemiology, Smolensk State Medical University, Ministry of Health of the Russia, Smolensk, Russia; mshipilov72@gmail.com; https://orcid.org/0009-0003-3238-1784
Mikhail V. Shipilov, MD,, Professor, Department of Infectious Diseases, Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russia, Moscow, Russia; Associate Professor, Department of Infectious Diseases with Epidemiology, Smolensk State Medical University, Ministry of Health of the Russia, Smolensk, Russia; mshipilov72@gmail.com; https://orcid.org/0009-0003-3238-1784
Alexandra A. Luzhetskayа, Graduate Student, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Moscow, Russia; luzhetskaya.98@mail.ru; https://orcid.org/0009-0004-6748-6786
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