Characteristics of the combined course of pertussis and seasonal coronavirus infection in children


DOI: https://dx.doi.org/10.18565/epidem.2025.15.4.74-81

Popova O.P., Bunin S.V., Trushakova S.V., Shvetsova Yu.V., Fedorova I.M., Koteleva S.I., Zharikova K.V.

1) Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russia, Moscow, Russia; 2) G.N. Gabrichevsky Moscow Research Institute of Microbiology and Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 3) Infectious Diseases Clinical Hospital № 1, Department of Healthcare of the city of Moscow, Moscow, Russia; 4) N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russia, Moscow, Russia
Objective: Evaluation of the characteristics of the concomitant course of pertussis and seasonal coronavirus infection in children.
Materials and methods. Data from 25 patients with pertussis and seasonal coronavirus infection hospitalized in the specialized department of the Infectious Diseases Clinical Hospital № 1 of the Department of Healthcare of the city of Moscow in 2023–2024 were analyzed. PCR and serological diagnostics (ELISA) were used to verify pertussis. Diagnosis of viral infections was based on PCR testing of nasopharyngeal mucus.
Results. Combination of pertussis with and seasonal coronavirus infection occurred predominantly in moderate form in 19 children (76.0 ± 8.5%), while severe forms were observed in only 6 patients (24.0 ± 8.5%). In nasopharyngeal mucus, among the seasonal coronavirus species, HCoV HKU1 was isolated from 8 patients with pertussis (32.0 ± 9.3%), HCoV-NL63 – from 11 (44.0 ± 9.9%), and HCoV-OC43 – from 6 (24.0 ± 8.5%). Studies have shown that the severity of pertussis, frequency, and nature of bronchopulmonary complications depended on the HCoV species.
Conclusion. The combination of pertussis and seasonal coronavirus infection among hospitalized patients was most often associated with HCoV-NL63. The clinical features of this mixed infection may be determined by the species of seasonal coronavirus. β-coronaviruses: HCoV-OC43 and HCoV-HKU1, had the most unfavorable effect on the course of pertussis.

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About the Autors


Olga P. Popova, МD, Professor, Department of Pediatric Infectious Diseases, ussian Medical Academy of Continuous Professional Education, Ministry of Health of the Russia; Leading Researcher, Department of Immunology, G.N. Gabrichevsky Moscow Research Institute of Microbiology and Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; doctorpopova@yandex.ru; http://orcid.org/0000-0002-1772-5978
Sergey V. Bunin, Head, 3rd Pediatric Department, Infectious Diseases Clinical Hospital № 1, Department of Healthcare of the city of Moscow, Moscow, Russia; bunin_sergey72@mail.ru
Svetlana V. Trushakova, Cand Biol. Sci., Senior Researcher, Laboratory of Influenza Etiology and Epidemiology, N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russia, Moscow, Russia; s.trushakova@gmail; http://orcid.org/0000-0002-9610-3041
Yulia V. Shvetsova, Pediatrician, 9th Pediatric Department of Infectious Diseases, Infectious Diseases Clinical Hospital № 1, Department of Healthcare of the city of Moscow, Moscow, Russia; juliashvetsova1983@gmail.ru; http://orcid.org/0009-0004-0151-7164
Irina M. Fedorova, Cand Med. Sci., Leading Researcher, Laboratory for the Study of Cellular and Molecular Bases of Immunity, G.N. Gabrichevsky Moscow Research Institute of Microbiology and Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 1vestnik-07@mail.ru; http://orcid.org/0000-0002-0335-2752
Svetlana I. Koteleva, Cand Med. Sci., Leading Researcher, Laboratory for the Study of the Cellular and Molecular Bases of Immunity, G.N. Gabrichevsky Moscow Research Institute of Microbiology and Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; felileo@yandex.ru; http://orcid.org/0000-0003-1878-2234
Ksenia V. Zharikova, Pediatrician, 9th Pediatric Department of Infectious Diseases, Infectious Diseases Clinical Hospital № 1, Department of Healthcare of the city of Moscow, Moscow, Russia; doctorzharikova@mail.ru; http://orcid.org/0009-0006-7317-4492


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