Русский
HIV-associated tuberculosis in the Astrakhan Region
DOI: https://dx.doi.org/10.18565/epidem.2025.15.3.19-23
Stepanova N.A., Vasilkova V.V., Bedlinskaya N.R., Duysalieva K.M., Filipyuk A.E.
Astrakhan State Medical University, Ministry of Health of the Russia, Astrakhan, Russia
Materials and methods. A clinical and epidemiological analysis of 87 cases of HIV-associated TB was conducted for the period from 2016 to 2024 in the AR.
Results. A tendency towards an increase in the incidence rate was revealed over the studied period. The challenging situation was associated with late patient seeking medical care and untimely initiation of therapy. The prevalence of disseminated and generalized TB (73.5%) was noted against the background of severe immunodeficiency (the number of CD4+ lymphocytes < 100 cells/μl in 86% of cases). Among the concomitant pathologies, socially significant diseases were observed: hepatitis C and B, alcoholism, drug addiction, while hepatitis C and B prevailed in men – 97.1%, and alcohol dependence prevailed in women - 88.9%.
Conclusion. The risk group for co-infection (HIV/TB) included unemployed male patients of working age, living in the city, with bad habits, followed-up in the State Healthcare Institution of the Astrakhan Region «Regional Center for the Prevention and Control of AIDS» for more than 3 years.
Literature
1. Семенова Н.Ю., Чеботарева Т.В., Орлова С.Н., Облогина Л.И. Клинико-морфологическая характеристика и исходы туберкулезного процесса у больных, страдающих ВИЧ-инфекцией. Эпидемиология и инфекционные болезни 2016; 21(6): 313–321. DOI: 10.18821/1560-9529-2016-21-6-313-321 Semenova N.Yu., Chebotareva T.V., Orlova S.N., Oblogina L.I. [Clinical and morphological characteristics and outcomes of the tuberculosis process in patients suffering from HIV infection]. Epidemiology and infectious diseases 2016; 21(6): 313–321. (In Russ.). DOI: 10.18821/1560-9529-2016-21-6-313-321 2. Бородулина Е.А., Вдоушкина Е.С., Кузнецова А.Н., Гладунова Е.П. Особенности коморбидной патологии (ВИЧ/туберкулез) при летальных исходах. ВИЧ-инфекция и иммуносупрессии 2019; 11(4): 70–78. DOI: 10.22328/2077-9828-2019-11-4-70-78 Borodulina E.A., Vdovushkina E.S., Kuznetsova A.N., Gladunova E.P. [Features of comorbid pathology (HIV/tuberculosis) in fatal cases]. HIV infection and immunosuppression 2019; 11(4): 70–78. (In Russ.). DOI: 10.22328/2077-9828-2019-11-4-70-78 3. Афанасьев Е.И., Русских О.Е. Современные тенденции в эпидемиологии туберкулеза и ВИЧ-инфекции в мире и в Российской Федерации. РМЖ 2021; (3): 24–26. Afanasyev E.I., Russkikh O.E. [Modern trends in the epidemiology of tuberculosis and HIV infection in the world and in the Russian Federation]. RMJ 2021; (3): 24–26. (In Russ.). 4. Чабанова О.Н., Рыжкова О.А., Стрельцова Е.Н., Сайфулин М.Х. ВИЧ-инфекция как одна из причин смерти больных туберкулезом. Астраханский медицинский журнал 2021; 16(4): 39–45. DOI: 10.17021/2021.16.4.39.45 Chabanova O.N., Ryzhkova O.A., Streltsova E.N., Saifullin M.H. [HIV infection as one of the causes of death of tuberculosis patients]. Astrakhan Medical Journal 2021; 16(4): 39–45. (In Russ.). DOI: 10.17021/2021.16.4.39.45 5. Рыжкова О.А., Чабанова О.Н., Стрельцова Е.Н., Сайфулин М.Х., Мустафин Р.Д. Клинико-эпидемиологические особенности течения туберкулеза в Астраханской области. Астраханский медицинский журнал 2021; 16 (4): 14–23. DOI: 10.17021/2021.16.4.14.23 Ryzhkova O.A., Chabanova O.N., Streltsova E.N., Saifullin M.H. Mustafin R.D. [Clinical and epidemiological features of tuberculosis in the Astrakhan Region]. Astrakhan Medical Journal 2021; 16 (4): 14–23. (In Russ.). DOI: 10.17021/2021.16.4.14.23 6. Покровская А.В., Козырина Н.В., Гущина Ю.Ш., Юрин О.Г., Суворова З.К., Покровский В.В. Социально-демографический портрет пациента, живущего с ВИЧ и посещающего центры СПИД в России. Терапевтический архив 2016; 88(11): 12–16. DOI: 10.17116/terarkh2016881112-16 Pokrovskaya A.V., Kozyrina N.V., Gushchina Yu.Sh., Yurin O.G., Suvorova Z.K., Pokrovsky V.V. [Socio-demographic portrait of a patient living with HIV and visiting AIDS centers in Russia]. Therapeutic archive 2016; 88(11): 12–16. (In Russ.). DOI: 10.17116/terarkh2016881112-16 7. Зимина В.Н., Кравченко А.В., Викторова И.Б., Кошечкин В.А. Туберкулез и ВИЧ-инфекция. Руководство 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа, 2020. 256 с. Zimina V.N., Kravchenko A.V., Viktorova I.B., Koshechkin V.A. [Tuberculosis and HIV infection]. Manual 2nd edition, revised and supplemented Moscow: GEOTAR-Media, 2020. 256 p. (In Russ.). 8. Пантелеев А.М., Никулина О.В., Драчева М.С., Пантелеева О.В. Критерии своевременной диагностики туберкулеза у пациентов с ВИЧ-инфекцией. Медицинский совет 2016; 10: 120–124. DOI: 10.21518/2079-701X-2016-10-120-124 Panteleev A.M., Nikulina O.V., Dracheva M.S., Panteleeva O.V. [Criteria for timely diagnosis of tuberculosis in patients with HIV infection]. Medical Council 2016; 10: 120–124. (In Russ.). DOI: 10.21518/2079-701X-2016-10-120-124 9. Викторова И.Б., Зимина В.Н., Кравченко А.В., Ханин А.Л. Бактериовыделение у пациентов с ВИЧ-инфекцией и туберкулезом. Эпидемиология и инфекционные болезни 2018; 3: 35–40. DOI: 10.18565/epidem.2018.3.35-40 Viktorova I.B., Zimina V.N., Kravchenko A.V., Khanin A.L. [Bacteriological isolation in patients with HIV infection and tuberculosis]. Epidemiology and infectious diseases 2018; 3: 35–40. (In Russ.). DOI: 10.18565/epidem.2018.3.35-40
About the Autors
Natalia A. Stepanova, МD, Professor, Department of Phthisiology, Astrakhan State Medical University, Ministry of Health of the Russia, Astrakhan, Russia; stepaniida@yandex.ru; http://orcid.org/0000-0002-5693-3462
Vera V. Vasilkova, МD, Associate Professor, Head, Department of Infectious Diseases and Epidemiology, Astrakhan State Medical University, Ministry of Health of the Russia, Astrakhan, Russia; vasilkova.ver@yandex.ru; http://orcid.org/0000-0002-7539-1910
Nadiya R.Bedlinskaya, Cand. Med. Sci., Associate Professor, Department of Infectious Diseases and Epidemiology, Astrakhan State Medical University, Ministry of Health of the Russia, Astrakhan, Russia; nadiyabedlinskaya@mail.ru; http://orcid.org/0000-0001-7626-1918
Karina M. Duysalieva, 5th year Student, Faculty of Pediatrics, Astrakhan State Medical University, Ministry of Health of the Russia, Astrakhan, Russia; karina.duysalieva@gmail.com; http://orcid.org/ 0009-0007-8283-4031
Anastasia E. Filipyuk, 5th year Student, Faculty of Pediatrics, Astrakhan State Medical University, Astrakhan, Ministry of Health of the Russia, Russia; filipuk@list.ru; http://orcid.org/0000-0002-1551-0148
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