Русский
Correlation assessment of the relationship between selenium levels and some indicators of oxidative stress in the blood serum in patients with tick-borne rickettsiosis in the South of the Khabarovsk Territory
DOI: https://dx.doi.org/10.18565/epidem.2024.14.1.71-6
Mokretsova E.V., Tomilka G.S., Kovalsky Yu.G., Yakusheva N.Yu., Shchupak A.Yu., Maleev V.V.
1) Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk, Russia; 2) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
Materials and methods. The Se levels and some chemiluminescence indicators in patients with a moderate form of TBR were analyzed.
Results. It was found that the mean blood serum Se level of the examined patients at the height of the disease was statistically significantly reduced, which was combined with a significant initiation of free radical oxidation processes and a sharp suppression of the mobilization of antioxidant antiradical defense. During the period of convalescence in patients with TBR, despite the extinction of the main clinical manifestations of the disease, the activity of free radical oxidation processes continued to increase. Correlation analysis revealed a reliable moderate negative relationship between the chemiluminescent parameters of short-lived reactive oxygen species and the blood serum Se level.
Conclusion. The data obtained indicate the conjugation of the processes of selenium and oxidative status. Se deficiency is reflected in a decrease in the activity of antioxidant antiradical defense.
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About the Autors
Evgenia V. Mokretsova, Cand. Med. Sci., Associate Professor, Department of Infectious Diseases and Epidemiology, Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk, Russia; bremer68@mail.ru; https://orcid.org/0000-0001-9492-2660
Professor Gennady S. Tomilka, MD, Head, Department of Infectious Diseases and Epidemiology, Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk, Russia; genntom@mail.fesmu.ru. https://orcid.org/0000-0002-8785-2147
Professor Yuri G. Kovalsky, MD, Head, Department of Biological Chemistry and Clinical Laboratory Diagnostics, Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk, Russia; kovalyura@mail.ru; https://orcid.org/0000-0001-7433-6285
Natalya Yu. Yakusheva, Cand. Pharm. Sci., Associate Professor, Department of Pharmacy and Pharmacology, Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk, Russia; whiteout@mail.ru; https://orcid.org/0000-0003-1561-5465
Alexander Yu. Shchupak, Cand. Med. Sci., Associate Professor, Head, Department of Clinical Toxicology and Extreme Medicine, Far Eastern State Medical University, Ministry of Health of Russia, Khabarovsk, Russia; schupakalex@mail.ru. https://orcid.org/0000- Professor 0001-6255-7638
Professor Viktor V. Maleev, Academician of the Russian Аcademy of Sciences, MD,, Advisor to the Director for Scientific Work, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; maleyev@pcr.ru. https://orcid.org/0000-0001-5748-178X
