Русский
Multidrug-resistant tuberculosis in patients with HIV infection in the CIS countries
DOI: https://dx.doi.org/10.18565/epidem.2021.11.3.78-83
Zimina V.N., Kravchenko A.V., Kulabukhova E.I., Suvorova Z.K., Pokrovskaya А.V., Khokhlova О.N., Vinokurova O.O., Li E.A., Kadyrova A.A., Papoyan A.S., Oganisyan R.A., Kralko V.Ya., Klimuk D.A., Bekbolotov A.A., Abdrakhmanova E.D., Soliev A.A., A’zamova Sh.A., Volchenkov G.V., Zamkovaya T.N., Pokrovsky V.V.
1) Peoples’ Friendship University of Russia, Moscow, Russia; 2) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 3) Center for Advanced Technologies in Health, Moscow, Russia; 4) Research Institute of Lung Diseases, Ministry of Health of the Republic of Azerbaijan, Baku, Azerbaijan; 5) Astghik Medical Center, Yerevan, Republic of Armenia; 6) Professor R.O. Yeolyan Hematology Center, Yerevan, Republic of Armenia; 7) Republican Scientific and Practical Center of Pulmonology and Phthisiology, Minsk, Republic of Belarus; 8) Republican AIDS Center, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; 9) National Center of Phthisiology, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; 10) Republican Center for AIDS Prevention and Control, Ministry of Health and Social Protection of the Population of the Republic of Tajikistan, Dushanbe, Tajikistan; 11) Republican Center for Protection of the Population from Tuberculosis, Dushanbe, Tajikistan; 12) Vladimir Regional Center for Specialized Phthisiopulmonological Care, Vladimir, Russia; 13) Vladimir Regional Center for AIDS Prevention and Control, Regional Clinical Hospital, Vladimir, Russia
Materials and methods. Epidemiological data were analyzed in the Republic of Azerbaijan, the Republic of Armenia, the Republic of Belarus, the Kyrgyz Republic, the Republic of Tajikistan, and the Vladimir Region of the Russian Federation. The data sources were national cases databases, state data registers, departmental statistical reports, the data of phthisiological services and state statistical services, as well as regular reports submitted by the countries to the WHO and UNAIDS.
Results. The cumulative assessment of changes in the number of all registered cases in the countries over the period of 2010–2018 suggests that there may be an increase in the number of patients with MDR-TB. During the study period, the coverage of the population by drug susceptibility testing (DST) for the pathogen gradually increased; however, the rate of coverage growth did not always correspond to the increase in the absolute number of incident MDR-TB cases. As this took place, DST was carried out for all incident TB cases in the Republic of Belarus and in the Vladimir Region. A comparison of HIV/TB cases and all TB cases showed that the pathogen resistance as a minimum to rifampicin (RR-TB) was more common in patients with HIV/TB co-infection. The success rates of MDR-TB treatment in HIV-infected patients still significantly lag behind those in drug-susceptible TB (DS-TB) and show no considerable changes during the follow-up period.
Conclusion. The detailed analysis of the prevalence of MDR-TB among the people living with HIV is of great prognostic importance for assessing the epidemic situation as a whole, calculating the funding of TB control programs, and improving the control over the disease and the efficiency of treatment.
Literature
1. WHO. Global Tuberculosis Report, 2020. https://www.who.int/teams/ global-tuberculosis-programme/tb-reports 2. Laurence Y.V., Griffiths U.K., Vassall A. Costs to Health Services and the Patient of Treating Tuberculosis: A Systematic Literature Review. Pharmacoeconomics 2015; 33(9): 939–55. doi: 10.1007/s40273-015-0279-6; PMID: 25939501; PMCID: PMC4559093 3. WHO. Global Tuberculosis Report, 2018. https://www.who.int/teams/ global-tuberculosis-programme/tb-reports 4. Sultana Z.Z., Hoque F.U., Beyene J., Akhlak-Ul-Islam M., Khan M.H.R., Ahmed S. et al. HIV infection and multidrug resistant tuberculosis: a systematic review and meta-analysis. BMC Infect. Dis. 2021; 21(1): 51. doi: 10.1186/s12879-020-05749-2. Erratum in: BMC Infect Dis. 2021 Jan 20; 21(1): 86. PMID: 33430786; PMCID: PMC7802168 5. WHO operational handbook on tuberculosis: module 4: treatment: drug-resistant tuberculosis treatment (2020). https://www.who.int/publications/i/item/9789240007048 6. WHO. Definitions and reporting framework for tuberculosis – 2013 revision. Geneva, Switzerland: Wolters Kluwer Health, 2013. 40 p.
About the Autors
Vera N. Zimina, MD, Professor of the Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, Peoples’ Friendship University of Russia; vera-zim@yandex.ru; https://orcid. org/0000-0003-3726-9022
Professor Alexey V. Kravchenko, MD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; alexey-kravtchenko@yandex.ru; http://orcid.org/0000-0001-7857-3763
Ekaterina I. Kulabukhova, Head, Laboratory of the Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, Peoples’ Friendship University of Russia; Infectiologist, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; ekulabukhova@mail.ru; https://orcid.org/0000-0003-3645-7275
Zoya K. Suvorova, Cand. Biol. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; zksu@inbox.ru; https://orcid.org /0000-0003-4055-289X
Anastasia V. Pokrovskaya, Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, Peoples’ Friendship University of Russia; Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service Supervision of Consumer Rights Protection and Human Well-Being; pokrovskaya_av@mail.ru; http://orcid.org/0000-0002-2677-0404
Olga N. Khokhlova, Cand. Med. Sci., Laboratory Doctor, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; x.olia79@mail.ru; https://orcid.org/0000-0001-9736-4043
Olga O. Vinokurova, Cand. Med. Sсi., Assistant Professor, Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, Peoples’ Friendship University of Russia; olga.berejnaya12@gmail.com; https://orcid.org/0000-0001-5689-7628
Ekaterina A. Li, Head, Research Program Supervisor, Center for Advanced Technologies in Healthcare; kh.yekaterina@gmail.com; https://orcid.org/0000-0002-8239-0713
Professor Agigat A.-K. Kadyrova, MD, Director, Research Institute of Lung Diseases, Ministry of Health of the Azerbaijan Republic; dr.kadyrovah@mail.ru; https://orcid.org/0000-0001-5297-9191
Arshak S. Papoyan, Epidemiologist, Republican Center «ASTGHIK»; arshak.papoyan1@gmail.com; https://orcid.org/0000-0002-4454-5163
Ruben А. Hovhannisyan, Epidemiologist, Professor R.H. Yeolyan Haematology Center; ruben.hovhannisyan77@gmail.com; https://orcid.org/0000-0002-0272-3371
Viktoryia Ya. Kralko, Deputy Director for Organizational and Methodological Work, Republican Scientific and Practical Center of Pulmonology and Phthisiology; kralko2017@gmail.com; http://orcid.org/0000-0003-3186-0751
Dmitry A, Klimuk, Нead, Department of the Phthisiopulmonological Monitoring and Evaluation, Republican Scientific and Practical Center of Pulmonology and Phthisiology; dzklm99@yahoo.com; https://orcid.org/0000-0002-0222-5583
Aibek A. Bekbolotov, Deputy Director, Republican AIDS Center, Ministry of Health of the Kyrgyz Republic; aibek_0001@mail.ru; https://orcid.org/0000-0001-9931-3311
Elvira D. Abdrakhmanova., Head, Department of Informatics and Epidemiology, National Center of Phthisiology, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; elmiraa1@yandex.ru; https://orcid.org/0000-0001-8754-2985
Alijon A. Soliev, Cand. Med. Sci., Deputy Director, Republican Center for AIDS Prevention and Control, Ministry of Health and Social Protection of the Population of the Republic of Tajikistan; salijon@mail.ru; https://orcid.org/0000-0001-6022-854X
Shahnoza А. Azamova, Deputy Director, Republican Center for the Protection of the Population from Tuberculosis; azamova.shahnoza@mail.ru
Grigoriy V.Volchenkov, Chief Physician, Centre for Specialised Phthisiopulmonological Care; root@tubdisp.elcom.ru
Tatyana N. Zamkovaya, Head, Regional Center for the Prevention and Control of AIDS, Vladimir Regional Clinical Hospital; aids.doctor@yandex.ru
Professor Vadim V. Pokrovsky, Academician of the Russian Academy of Sciences MD, Head, HIV Department, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; pokrovsky.vad@yandex.ru; https://orcid.org/0000-0002-9514-7288
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