Русский
Clinical case of tick-borne spotted fever rickettsiosis without a rash
DOI: https://dx.doi.org/10.18565/epidem.2021.11.1.57-61
Perfilyeva Yu.V., Ostapchuk E.O., Naizabayeva D.A., Neupokoyeva A.S., Turebekov N.A., Yeraliyeva L.T., Dmitrovsky A.M.
1) Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Kazakhstan; 2) M. Aikimbayev National Research Center for Especially Dangerous Infections, Ministry of Healthcare of the Republic of Kazakhstan, Almaty, Kazakhstan; 3) National Research Center of Phthisiopulmonology, Ministry of Healthcare of the Republic of Kazakhstan, Almaty, Kazakhstan
Materials and methods. The discrepancies in the primary and final diagnoses were analyzed. A retrospective analysis of the clinical manifestations and dynamics of the disease was carried out on the basis of the patient’s medical history. A retrospective serological analysis for immunoglobulins to Rickettsia of the tick-borne spotted fever group was carried out by an enzyme immunoassay.
Results. Upon admission, the patient had a fever, intoxication syndrome, hyperemia of the pharynx, hemorrhages of the soft palate, enlarged liver, positive reactions to brucellosis, a history of chronic brucellosis, while no skin rash was observed. The study of serum taken from the patient on day 13 of the disease revealed IgM and IgG against rickettsia of the spotted fever group.
Conclusion. There is an urgent need to introduce a comprehensive laboratory and etiological examination of febrile patients for tick-borne rickettsioses in Southern Kazakhstan, including the Almaty Region.
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About the Autors
Yulia V. Perfilyeva, PD, Leading Researcher, Laboratory of Expertise and Diagnosis, Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Republic of Kazakhstan; ulya2005@mail.ru; https://orcid.org/0000-0001-6803-0773
Ekaterina O. Ostapchuk, PD, Leading Researcher, Laboratory of Molecular Biology, Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Republic of Kazakhstan; katyostapchuk@gmail.com; https://orcid.org/0000-0002-3771-423X
Dinara A. Naizabayeva, Junior Researcher, Laboratory of Expertise and Diagnosis, Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Republic of Kazakhstan; dino_n7@mail.ru; https://orcid.org/0000-0002-0606-4289
Alena S. Neupokoyeva, Senior Researcher, Laboratory of Expertise and Diagnosis, Almaty Branch of National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Republic of Kazakhstan; cherusheva_a@mail.ru; https://orcid.org/0000-0001-7257-8037
Nurgeldy A. Turebekov, PD, Leading Researcher, M. Aikimbayev National Research Center for Especially Dangerous Infections, Almaty, Republic of Kazakhstan; nirik_1976@mail.ru; https://orcid.org/0000-0001-6826-2611
Professor Lyazzat T. Yeraliyeva, MD, Deputy Director for Clinical and Scientific Work, National Research Center of Phthisiopulmonology, Almaty, Republic of Kazakhstan; l.eralieva@mail.ru; https://orcid.org/0000-0002-0892-166X
Professor. Аndrey M. Dmitrovsky, MD, Head, Laboratory of Expertise and Diagnosis, Almaty Branch, National Center for Biotechnology, Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Republic of Kazakhstan; am_dmitr@mail.ru; https://orcid. org/0000-0003-4714-3079
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