Tuberculosis trends in HIV-infected patients in the CIS countries in 2014-2018


DOI: https://dx.doi.org/10.18565/epidem.2020.10.3.47-53

Kravchenko A.V., Pokrovskaya A.V., Kula­bukhova E.I., Zimina V.N., Suvorova Z.K., Khokh­lova O.N., Li E.A., Zamkovaya T.N., Ka­dy­rova A.A., Papoyan A.S., Svetogor T.N., Soliev A.A., Bekbolotov A.A., Bekmetova M.Yu., Pokrovsky V.V.

1) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 2) Peoples’ Friendship University of Russia, Moscow, Russia; 3) Autonomous Nonprofit Organization «Center for Advanced Technologies in Healthcare», Moscow, Russia; 4) Regional Center for AIDS Prevention and Control, Vladimir Regional Clinical Hospital, Vladimir, Russia; 5) Research Institute of Lung Diseases, Ministry of Health of the Azerbaijan Republic, Baku, Azerbaijan; 6) Republican Center for AIDS Prevention, Ministry of Health of the Republic of Armenia, Yerevan, Armenia; 7) Republican Center for Hygiene, Epidemiology, and Public Health, Minsk, Republic of Belarus; 8) Republican AIDS Center, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; 9) Republican Center for AIDS Prevention and Control, Ministry of Health and Social Protection of the Population of the Republic of Tajikistan, Dushanbe, Tajikistan; 10) Republican Center for AIDS Control, Ministry of Health of the Republic of Uzbekistan, Tashkent, Uzbekistan
Objective. To estimate tuberculosis (TB) morbidity and mortality rates in the general population and HIV-infected patients in six CIS countries (Azerbaijan, Armenia, Belarus, Kyrgyzstan, Tajikistan, and Uzbekistan) and in the Vladimir Region (the Russian Federation) in 2014–2018.
Materials and methods. National statistics, as well as materials of the countries’ regular reporting to the WHO and UNAIDS were used as main sources.
Results. All of the above participating countries showed a reduction in TB morbidity and mortality rates during the study period. The TB morbidity rates in HIV patients (per 100,000 patients) were significantly higher than those in the general population of Azerbaijan and Armenia (by 19.2 and 134.7 times greater, respectively). Among the HIV-infected patients who died from secondary diseases, the number of TB deaths was minimal in the Republic of Belarus (16.3%) and in the Vladimir Region (21.4%). In the other participating countries, TB was the cause of death in nearly half of HIV-infected patients (49.2–54.2%).
Conclusion. Despite a clear trend towards the decrease in TB mortality rates in the CIS countries, the problem of HIV/TB co-infection is undoubtedly of relevance in this region.
Keywords: CIS countries, TB/HIV co-infection, tuberculosis, morbidity, mortality
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About the Autors

Prof. Alexey Kravchenko, MD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: alexey-kravtchenko@yandex.ru; ORCID: http://orcid.org/0000-0001-7857-3763
Anastasia V. Pokrovskaya, Cand. Med. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: pokrovskaya_av@mail.ru; ORCID: http://orcid. org/0000-0002-2677-0404
Ekaterina I. Kulabukhova, Infectiologist, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Head, Laboratory of the Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, Peoples’ Friendship University of Russia, Moscow, Russia; e-mail: ekulabukhova@mail.ru; ORCID: https://orcid.org/0000-0003-3645-7275
Vera N. Zimina, MD, Professor, Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, Peoples’ Friendship University of Russia, Moscow, Russia; e-mail: vera-zim@yandex.ru; ORCID: https:// orcid.org/0000-0003-3726-9022
Zoya K. Suvorova, Cand. Biol. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: zksu@inbox.ru; ORCID: https://orcid.org /0000-0003-4055-289X
Olga N. Khokhlova, Cand. Med. Sci., Laboratory Doctor, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: x.olia79@mail.ru; ORCID: https://orcid.org/0000-0001-9736-4043
Ekaterina A. Li, Head, Research Program Supervisor, Center for Advanced Technologies in Healthcare, Moscow, Russia; e-mail: kh.yekaterina@gmail.com
Tatiana N. Zamkovaya, Head, Regional Center for AIDS Prevention and Control, Vladimir Regional Clinical Hospital, Vladimir, Russia; e-mail: aids.doctor@yandex.ru
Prof. Agigat A.-K. Kadyrova, MD, Director, Research Institute of Lung Diseases, Ministry of Health of the Azerbaijan Republic, Baku, Azerbaijan; e-mail: dr.kadyrovah@mail.ru; ORCID: https://orcid.org/0000-0001-5297-9191
Arshak S. Papoyan, Epidemiologist, Republican Center for AIDS Prevention, Ministry of Health of the Republic of Armenia, Yerevan, Armenia; e-mail: arshak.papoyan1@gmail.com; ORCID: https://orcid.org/0000-0002-4454-5163
Tamara N. Svetogor, Epidemiologist; Head, Department for Prevention of HIV Infection and Parenteral Viral Hepatitides, Republican Center for Hygiene, Epidemiology, and Public Health, Minsk, Republic of Belarus; e-mail: svetogor_tamara@mail.ru
Alijon A. Soliev, Cand. Med. Sci., Deputy Director, Republican Center for AIDS Prevention and Control, Ministry of Health and Social Protection of the Population of the Republic of Tajikistan; Dushanbe, Tajikistan; e-mail: salijon@mail.ru
Aibek A. Bekbolotov, Deputy Director, Republican AIDS Center, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; e-mail: aibek_0001@mail.ru; ORCID: https://orcid.org/0000-0001-9931-3311
Mubarak Yu. Bekmetova, Highest Category Infectiologist; Head, Polyclinic, Republican Center for AIDS Control, Ministry of Health of the Republic of Uzbekistan, Tashkent, Uzbekistan; e-mail: yuldashovna@mail.ru
Prof. Vadim V. Pokrovsky, Academician of the Russian Academy of Sciences MD, Head, HIV Department, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: pokrovsky.vad@yandex.ru; ORCID: https://orcid.org/0000-0002-9514-7288


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