Strategy for design of antistaphylococcal drugs for immunoprophylaxis and immunotherapy


Gruber I.M., Egorova N.B., Kurbatova E.A., Mikhailova N.A.

I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow
Numerous efforts by a number of research organizations to design staphylococcus vaccines have been unsuccessful to this day and there are virtually unavailable effective commercial immunopreparations to control staphylococcal infections. The review presents the results of trials of vaccines designed using the major virulence factors of Staphylococcus aureus. Foremost, these are capsular polysaccharides, alpha-toxin, leukocidin, and surface protein antigens. During the clinical trials, the vaccines based on these antigens proved to be insufficiently effective; in this connection, a start was made to develop polyvalent vaccines by choosing protective antigens. These vaccines were designed on the basis of surface proteins, including iron-regulated ones. There are also attempts to develop vaccines based on polysaccharide-protein compositions obtained from specially selected S.aureus strains. Virtually all multivalent vaccines are passing a clinical stage or phase 1 clinical trial now. To select S. aureus strains and to choose protective antigens are an important condition for preparing an effective staphylococcal vaccine; these have been used to design the vaccine developed at the I.I. Mechnikov Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences.

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About the Autors


Prof. Gruber Irina Mironovna, MD; Head, Laboratory of Experimental Microbiology, I.I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences
Address: 5a, Malyi Kazennyi Per., Moscow 105064
Telephone: +7(495) 916–20–47
E-mail: igruber_instmech@mail.ru


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